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BAFF-R (DM143) Rabbit mAb

Anti-BAFF-R (DM143) Rabbit Monoclonal Antibody
5/5

$445.00

Cat.#:  28487

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28487
Product Name:   Anti-BAFF-R(DM143) Rabbit Monoclonal Antibody
Synonyms:   BAFFR;TNFRSF13C;BAFF-R;BROMIX;CD268;CVID4;prolixin
Description:    Anti-BAFF-R antibody(DM143) Rabbit Monoclonal Antibody
Background:    B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also; some SLE patients have increased levels of BAFF in serum. Therefore; it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Applications:    ELISA; Flow Cyt
Recommended Dilutions:    ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit IgG
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human BAFF-R
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human BAFFR protein, mFc tagged protein 11170 can bind Rabbit anti-BAFFR monoclonal antibody (clone: DM143) in a linear range of 0.8-50

Figure 2. Flow cytometry analysis with Anti-BAFFR (DM143) on Expi293 cells transfected with human BAFFR (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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