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CCR2 (DMC447) IgG1 Chimeric mAb

Anti-CCR2 (DMC447) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28235

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28235
Product Name:   Anti-CCR2(DMC447) IgG1 Chimeric Monoclonal Antibody
Synonyms:   CC-CKR-2; MCP-1-R; CD192
Description:    Anti-CCR2 antibody(DMC447) IgG1 Chimeric Monoclonal Antibody
Background:    The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1; a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human CCR2
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-CCR2 (DMC447) on Expi293 cells transfected with human CCR2 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).