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Human CCR2 Full Length Protein

Human CCR2 Full Length Protein-Synthetic Nanodisc


Cat.#:  11011

   Size:   50 μg

In Stock

          Product Description          
Cat.#:     11011
Product Name:   Human CCR2 Full Length Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
Target:    CCR2
UNIPROT ID:    P41597
Description:    Human CCR2 full length protein-synthetic nanodisc
Background:     The protein is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.
Species/Host:    HEK293
Molecular Weight:    The human full length CCR2 protein has a MW of 41.9 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure1. Elisa plates were pre-coated with Flag Tag CCR2-Nanodisc (0.2 µg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with CCR2-Nanodisc is 7.62ng/ml.

Figure2. Human CCR2-Nanodisc, Flag Tag on SDS-PAGE

Figure3. WB analysis of Human CCR2-Nanodisc with anti-CCR2 monoclonal antibody (28090), followed by Goat Anti-Human IgG HRP at 1/5000 dilution