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CD112 (DMC224) IgG1 Chimeric mAb

Anti-CD112 (DMC224) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28173

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28173
Product Name:   Anti-CD112(DMC224) IgG1 Chimeric Monoclonal Antibody
Synonyms:   NECTIN2; HVEB; PRR2; PVRL2; PVRR2
Description:    Anti-CD112 antibody(DMC224) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus; and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants; encoding different isoforms; have been characterized.
Applications:    ELISA; Flow Cyt
Recommended Dilutions:    ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human CD112
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. CD112 protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-CD112 (DMC224) on Expi293 cells transfected with human CD112 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and  Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).