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cGMP mAb (Non-Acetylation)

Anti-cGMP Mouse Monoclonal Antibody
5/5

$495.00

Cat.#:  26001-2

   Size:   30 µL

In Stock

          Product Description          
cGMP mAb (Non-Acetylation)
Cat. #:   26001-2
Size:  30 µL
Description:   Anti-cGMP Mouse Monoclonal Antibody
Background: cGMP is a ubiquitous second  messenger mediating cellular responses to various exogenous and endogenous signaling molecules.  cGMP regulates physiological processes by activating protein kinases, gating specific ion  channels, and modulating cellular cyclic nucleotide concentrations through phosphodiesterases. The  conversion of GTP to cGMP is catalyzed by guanylyl cyclases (GCs). There are two types of  GCs in mammals: the soluble and the  membrane-bound GCs. The soluble GCs are  generally activated when nitric oxide binds to the attached prosthetic heme group. Seven  membrane-bound GCs (also named transmembrane  or particulated GCs) have been identified in the  human genome. GC-A and GC-B are natriuretic  peptide receptors. GC-C can be activated by  bacterial heat-stable enterotoxins, guanylin and  uroguanylin. The activity of transmembrane GCs  can also be modulated by other receptor signals  through intracellular signaling pathways.
Immunogen:   cGMP
Applications:   ELISA, WB, IHC
Recommended Dilutions:    ELISA 1:1000-1:5000 WB 1:500-1:2000
Concentration:    1 mg/ml
Host Species:   Mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:    IgG
Purity:   Purified from ascites
Preservative:  No
Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Storage Conditions:   Store at -20°C. Avoid repeated freezing and thawing
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          Publications          
01. Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer
J Ovarian Res. 2022
02. Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function
Thromb Haemost. 2022
03. PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
Commun Biol., 2022
04. Celecoxib reduces hepatic vascular resistance in portal hypertension by amelioration of endothelial oxidative stress
J Cell Mol Med. 2021
05. Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production
Front Pharmacol. 2021
06. Theacrine, a Potent Antidepressant Purine Alkaloid from a Special Chinese Tea, Promotes Adult Hippocampal Neurogenesis in Stressed Mice
J Agric Food Chem. 2021
07. Homogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases
Sci Rep., 2020
08. 17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase
J Biol Chem. 2019
09. Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling
Cells. 2019
10. DHA induces apoptosis of human malignant breast cancer tissues by the TLR-4/PPAR-α pathways
Oncol Lett. 2018
11. Ferulic acid induces proliferation and differentiation of rat osteoblasts in vitro through cGMP/PKGII/ENaC signaling
Oncol Lett. 2018
12. Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest
Theriogenology. 2018
13. Interplay between Obesity-Induced Inflammation and cGMP Signaling in White Adipose Tissue
Cell Rep. 2017
14. N-octanoylated ghrelin peptide inhibits bovine oocyte meiotic resumption
J Asian Nat Prod Res., 2017
15. Novel effect of Daflon and low-dose γ-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats
Hum Exp Toxicol. 2017
16. Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide
Oncotarget. 2017
17. Characterization and expression of soluble guanylate cyclase in skins and melanocytes of sheep
Acta Histochem. 2016
18. Cross regulation between cGMP-dependent protein kinase and Akt in vasodilatation of porcine pulmonary artery
J Control Release. 2016
19. Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium
Am J Physiol Regul Integr Comp Physiol. 2016
20. The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization
Am J Physiol Regul Integr Comp Physiol. 2016
21. Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy
Basic Res Cardiol. 2015
22. Identification of a novel microRNA important for melanogenesis in alpaca (Vicugna pacos)
J Anim Sci. 2015
23. Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4
Br J Pharmacol., 2014
24. Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting
Hepatology, 2014
25. Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase
Pflugers Arch. 2014
26. The effects of fusion structure on the expression and bioactivity of human brain natriuretic peptide (BNP) albumin fusion proteins
Curr Pharm Biotechnol. 2014
27. Defining Specificity Determinants of Cyclic GMP-Mediated Gustatory Sensory Transduction in Caenorhabditis elegans
Genetics. 2013
28. Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates the relaxation of porcine pulmonary arteries to nitric oxide
Pflugers Arch. 2013
29. The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice
Redox Biology, 2013
30. The Soluble Guanylate Cyclase Activator BAY 58-2667 Protects against Morbidity and Mortality in Endotoxic Shock by Recoupling Organ Systems
PLoS One. 2013
31. Volume overload induces differential spatiotemporal regulation of myocardial soluble guanylyl cyclase in eccentric hypertrophy and heart failure
Journal of Molecular and Cellular Cardiology, 2013
32. Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1
Pflugers Arch. 2012
33. Hypoxia induces downregulation of soluble guanylyl cyclase β1 by miR-34c-5p
J Cell Sci. 2012
34. Inhibition of phosphoinositide 3-kinase potentiates relaxation of porcine coronary arteries induced by nitroglycerin by decreasing phosphodiesterase type 5 activity
Circ J. 2012
35. Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity
Proc Natl Acad Sci U S A. 2012
36. Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation
Circ Res. 2012
37. Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism
PLoS One. 2011
38. Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish
Comp Biochem Physiol B Biochem Mol Biol. 2011
39. Molt-inhibiting hormone from Chinese mitten crab (Eriocheir sinensis): Cloning, tissue expression and effects of recombinant peptide on ecdysteroid secretion of YOs
Gen Comp Endocrinol. 2011
40. Role of sulfhydryl-dependent dimerization of soluble guanylyl cyclase in relaxation of porcine coronary artery to nitric oxide
Cardiovasc Res. 2011
41. Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes
Circ Res. 2010
42. Stimulation of guanylyl cyclase-D by bicarbonate
Biochemistry. 2009