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Human CLDN6 Full Length Protein

Human CLDN6 Full Length Protein-Synthetic Nanodisc


Cat.#:  11001

   Size:   50 μg

In Stock

          Product Description          
Cat.#:     11001
Product Name:   Human CLDN6 Full Length Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   Claudin 6; Claudin-6; Skullin;Claudin6
Target:    CLDN6
UNIPROT ID:    P56747
Description:    Human CLDN6 full length protein-synthetic nanodisc
Background:     Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Species/Host:    HEK293
Molecular Weight:    The human full length CLDN6 Protein has a MW of 23 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure1. Elisa plates were added with Flag Tag CLDN6-Nanodisc (0.5 µg/per well) on an anti-Flag monoclonal antibody pre-coated (0.5 µg/per well) plate. Serial diluted anti-CLDN6 monoclonal antibody (28085) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CLDN6 monoclonal antibody binding with CLDN6-Nanodisc is 66.99ng/ml.