Pioneering GTPase and Oncogene Product Development since 2010

Email us: info@neweastbio.com

Call us: 6109452007

Human CXCR6 Full Length Protein

Human CXCR6 Full Length Protein-Synthetic Nanodisc
5/5

$4,400.00

Cat.#:  11105

   Size:   50 μg

3-4 weeks

            Product Description          
Cat.#:     11105
Product Name:   Human CXCR6 Full Length Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   BONZO; CD186; CDw186; STRL33; TYMSTR
Target:    CXCR6
UNIPROT ID:    O00574
Description:    Human CXCR6 full length protein-synthetic nanodisc
Background:     A G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.
Species/Host:    HEK293
Molecular Weight:    The human full length CXCR6 protein has a MW of 39.3 kDa
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Publications