NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$219.00
Ga<sub>13</sub> Polyclonal Antibody
Cat. #: 21020 |
Gene Symbol: GNA13 |
Description: Anti-Ga13Rabbit Polyclonal Antibody |
Background: Heterotrimeric G proteins are essential cellular signal transducers. Gα13 is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Ga13 are being explored. |
Immunogen: A synthetic peptide from a unique region of Ga13 |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA: 1:100-1:5000 WB: 1:100-1:2000 IHC: 1:50-1:100 |
Concentration: 0.2 mg/ml |
Host Species: Rabbit |
Format: Liquid |
Clonality: Polyclonal |
Purity: Purified from serum |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Gα13 polyclonal antibody recognizes Gα13 of vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Purified Gα13 protein was blot with Anti-Gα13 polyclonal antibody (Cat # 21020). |
1. Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization J Biol Chem. 2011 Sep 2;286(35):31055-61 |
2. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Galpha and beta-arrestin-2 Br J Pharmacol. 2011 Feb;162(3):733-48 |
3. Gα12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation Carcinogenesis (2010) |
4. Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency J Biol Chem. 2009 Oct 2;284(40):27409-15 |