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Human ANGPT2(275-496) Protein, His Tag

Recombinant Human ANGPT2(275-496) Protein with C-terminal 6XHis tag


Cat.#:  11871

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11871
Product Name:   Human ANGPT2(275-496) Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   AGPT2;ANG2;LMPHM10
Target:    ANGPT2
UNIPROT ID:    O15123
Description:    Recombinant Human ANGPT2(275-496) Protein with C-terminal 6xHis tag
Background:     This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 26.3 kDa after removal of the signal peptide. The apparent molecular mass of ANGPT2(275-496)-His is approximately 25-35 kDa due to glycosylation.
Molecular Characterization:    ANGPT2(Lys275-Phe496) 6×His tag
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human ANGPT2(275-496) Protein, His Tag on SDS-PAGE under reducing condition.