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Human BMP6 Protein, His Tag

Recombinant human BMP6 protein with C-terminal 6XHis tag


Cat.#:  11788

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11788
Product Name:   Human BMP6 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   VGR;VGR1
Target:    BMP6
UNIPROT ID:    P22004
Description:    Recombinant human BMP6 protein with C-terminal 6xHis tag
Background:     This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 55.6 kDa after removal of the signal peptide. The apparent molecular mass of BMP6-His is approximately 40-70 kDa due to glycosylation.
Molecular Characterization:    BMP6(Cys21-His513) 6×His tag
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human BMP6 Protein, His Tag on SDS-PAGE under reducing condition.