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Human CCR2 Protein, mFc Tag

Recombinant human CCR2 protein with C-terminal mouse Fc tag


Cat.#:  11777

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11777
Product Name:   Human CCR2 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CC-CKR-2;MCP-1-R;CD192
Target:    CCR2
UNIPROT ID:    P41597
Description:    Recombinant human CCR2 protein with C-terminal mouse Fc tag
Background:     The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 31.1 kDa after removal of the signal peptide. The apparent molecular mass of CCR2-mFc is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    CCR2(Met1-Ala42) mFc(Pro99-Lys330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human CCR2 Protein, mFc Tag on SDS-PAGE under reducing condition.