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Human CFD Protein, hFc Tag

Recombinant Human CFD Protein with C-terminal human Fc tag
5/5

$389.00

Cat.#:  11970

   Size:   100 μg

In Stock

            Product Description          
Cat.#:     11970
Product Name:   Human CFD Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   ADIPSIN;ADN;DF;PFD
Target:    CFD
UNIPROT ID:    P00746
Description:    Recombinant Human CFD Protein with C-terminal human Fc tag
Background:     This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 50.5 kDa after removal of the signal peptide. The apparent molecular mass of CFD-hFc is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    CFD(Ile26-Ala253) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human CFD Protein, hFc Tag on SDS-PAGE under reducing condition.
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