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Human CLDN3 Protein, hFc Tag

Recombinant human CLDN3 protein with C-terminal human Fc tag


Cat.#:  11638

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11638
Product Name:   Human CLDN3 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   C7orf1;CPE-R2;CPETR2;HRVP1;RVP1
Target:    CLDN3
UNIPROT ID:    O15551
Description:    Recombinant human CLDN3 protein with C-terminal human Fc tag
Background:     Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 31.8 kDa after removal of the signal peptide. The apparent molecular mass of CLDN3-hFc is approximately 35-40 kDa due to glycosylation.
Molecular Characterization:    CLDN3(Arg30-Arg80) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human CLDN3 Protein, hFc Tag on SDS-PAGE under reducing condition.