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Human CLDN4(145-157) Protein, mFc Tag

Recombinant human CLDN4(145-157) Protein with C-terminal mouse Fc tag


Cat.#:  11845

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11845
Product Name:   Human CLDN4(145-157) Protein
Size :    10 µg, 50 µg and 100 µg
Target:    CLDN4
UNIPROT ID:    O14493
Description:    Recombinant human CLDN4(145-157) Protein with C-terminal mouse Fc tag
Background:     The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 27.7 kDa after removal of the signal peptide. The apparent molecular mass of CLDN4(145-157)-mFc is approximately 25-35 kDa due to glycosylation.
Molecular Characterization:    CLDN4(Gln145-Lys157) mFc(Pro99-Lys330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human CLDN4(145-157) Protein, mFc Tag on SDS-PAGE under reducing condition.