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| Cat.#: 12057 | ||||
| Product Name: Human IL-2 Superkine (Mutant | ||||
| Size : 10 µg, 50 µg and 100 µg | ||||
| Synonyms: Interleukin-2;IL-2;T-Cell Growth Factor;TCGF;Aldesleukin;IL2 | ||||
| Target: IL-2 | ||||
| UNIPROT ID: P60568 | ||||
| Description: “Recombinant Human Interleukin-2 Superkine is produced by our Mammalian expression system and the target gene encoding Ala21-Thr153 (L100F | ||||
| Background: Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells. | ||||
| Species/Host: HEK293 | ||||
| Molecular Weight: 16.5 KDa | ||||
| Molecular Characterization: Not available | ||||
| Purity: Greater than 95% as determined by reducing SDS-PAGE. | ||||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||||
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