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Human IL13(35-146) Protein, hFc Tag

Recombinant human IL13(35-146) protein with C-terminal human Fc tag


Cat.#:  11793

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11793
Product Name:   Human IL13(35-146) Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   IL-13;NC30
Target:    IL13
UNIPROT ID:    P35225
Description:    Recombinant human IL13(35-146) protein with C-terminal human Fc tag
Background:     This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 38.4 kDa after removal of the signal peptide. The apparent molecular mass of IL13(35-146)-hFc is approximately 33-53 kDa due to glycosylation.
Molecular Characterization:    IL13(Gly35-Asn146) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL13(35-146) Protein, hFc Tag on SDS-PAGE under reducing condition.