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Human IL18 Protein, mFc Tag

Recombinant Human IL18 with C-terminal mouse Fc tag
5/5

$479.00

Cat.#:  11358

   Size:   100 μg

In Stock

            Product Description          
Cat.#:     11358
Product Name:   Human IL18 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   IGIF;IL-1g;IL-18;IL1F4
Target:    IL18
UNIPROT ID:    Q14116
Description:    Recombinant Human IL18 with C-terminal mouse Fc tag
Background:     The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 44.3 kDa after removal of the signal peptide.The apparent molecular mass of IL18-mFc is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    IL18(Thr37-Asp197) mFc(Pro99-Lys330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL18 Protein, mFc Tag on SDS-PAGE under reducing condition.
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