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Human ITGB7 Protein, hFc Tag

Recombinant human ITGB7 protein with C-terminal human Fc tag


Cat.#:  11648

   Size:   100 μg

Under development

          Product Description          
Cat.#:     11648
Product Name:   Human ITGB7 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   integrin;beta 7;integrin beta 7 subunit
Target:    ITGB7
UNIPROT ID:    P26010
Description:    Recombinant human ITGB7 protein with C-terminal human Fc tag
Background:     This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 105.16 kDa after removal of the signal peptide.
Molecular Characterization:    ITGB7 (Glu20-His723) hFc (Glu99-Ala330) co-translates with ITGAE (Phe19-Ser1124) hFc (Glu99-Ala330).
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.