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Human PILRA Protein, hFc Tag

Recombinant Human PILRA Protein with C-terminal human Fc tag
5/5

$389.00

Cat.#:  11931

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11931
Product Name:   Human PILRA Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   FDF03
Target:    PILRA
UNIPROT ID:    Q9UKJ1
Description:    Recombinant Human PILRA Protein with C-terminal human Fc tag
Background:     Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 46.2 kDa after removal of the signal peptide. The apparent molecular mass of PILRA-hFc is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    PILRA(Gln20-Glu195) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human PILRA Protein, hFc Tag on SDS-PAGE under reducing condition.
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