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Human PRAME Protein, hFc Tag

Recombinant human PRAME protein with C-terminal human Fc tag


Cat.#:  11710

   Size:   100 μg

Under development

          Product Description          
Cat.#:     11710
Product Name:   Human PRAME Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CT130;MAPE;OIP-4;OIP4
Target:    PRAME
UNIPROT ID:    P78395
Description:    Recombinant human PRAME protein with C-terminal human Fc tag
Background:     This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 81.51 kDa after removal of the signal peptide.
Molecular Characterization:    PRAME (Met1-Asn509) hFc (Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.