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IL-6 (DMC419) IgG1 Chimeric mAb

Anti-IL-6 (DMC419) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28213

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28213
Product Name:   Anti-IL-6(DMC419) IgG1 Chimeric Monoclonal Antibody
Synonyms:   IL6; Interleukin-6; BSF2; HSF; IFNB2
Description:    Anti-IL-6 antibody(DMC419) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition; the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation; where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor; alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states; including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human IL-6
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-IL-6 (DMC419) on Expi293 cells transfected with human IL-6 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).