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IL21R (DMC225) IgG1 Chimeric mAb

Anti-IL21R (DMC225) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28174

   Size:   100 μg

In Stock

            Product Description          
Cat.#:   28174
Product Name:   Anti-IL21R(DMC225) IgG1 Chimeric Monoclonal Antibody
Synonyms:   CD360; IMD56; NILR
Description:    Anti-IL21R antibody(DMC225) IgG1 Chimeric Monoclonal Antibody
Background:    The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors; and has been shown to form a heterodimeric receptor complex with the common gamma-chain; a receptor subunit also shared by the receptors for interleukin 2; 4; 7; 9; and 15. This receptor transduces the growth promoting signal of IL21; and is important for the proliferation and differentiation of T cells; B cells; and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules; including JAK1; JAK3; STAT1; and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Applications:    ELISA; Flow Cyt
Recommended Dilutions:    ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human IL21R
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-IL21R (DMC225) on Expi293 cells transfected with human IL21R (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).