Cat.#: 11103 |
Product Name: Human MC4R Full Length Protein |
Size : 10 µg; 50 µg and 100 µg |
Synonyms: BMIQ20 |
Target: MC4R |
UNIPROT ID: P32245 |
Description: Human MC4R Full Length Protein-Synthetic Nanodisc |
Background: The protein is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. |
Species/Host: HEK293 |
Molecular Weight: The human full length MC4R protein has a MW of 36.9 kDa |
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Protein Families: Druggable Genome, GPCR, Transmembrane |
Protein Pathways: Neuroactive ligand-receptor interaction |
 Figure 1. Elisa plates were pre-coated with Flag Tag MC4R-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with MC4R-Nanodisc is 1.957ng/ml. |  Figure 2. Human MC4R-Nanodisc, Flag Tag on SDS-PAGE |
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