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Mouse BTLA Protein, mFc Tag

Recombinant mouse BTLA protein with C-terminal mFc tag


Cat.#:  11325

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11325
Product Name:   Mouse BTLA Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   BTLA;D272
Target:    BTLA
Description:    Recombinant mouse BTLA protein with C-terminal mFc tag
Background:     Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 42.7 kDa after removal of the signal peptide.The apparent molecular mass of Mouse-BTLA-mFc is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    Mouse BTLA(Glu30-Pro176) mFc(Pro99-Lys330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Mouse BTLA Protein, mFc Tag on SDS-PAGE under reducing condition.