NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$659.00
Cat.#: 12184 |
Product Name: Mouse CEACAM5 Protein |
Size : 10 µg, 50 µg and 100 µg |
Synonyms: Pregnancy-specific glycoprotein 30;Psg30 |
Target: CEACAM5 |
UNIPROT ID: Q3UKK2 |
Description: Recombinant mouse CEACAM5 protein with C-terminal 6xHis tag |
Background: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.[UniProtKB/Swiss-Prot Function] |
Species/Host: HEK293 |
Molecular Weight: The protein has a predicted molecular mass of 103.4kDa after removal of the signal peptide. The apparent molecular mass of mCEACAM5-His is approximately 130-180 kDa due to glycosylation. |
Molecular Characterization: Mouse CEACAM5(Gln35-Glu947) 6×His tag |
Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Mouse CEACAM5 Protein, His Tag on SDS-PAGE under reducing condition. |