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Mouse GITR Ligand Protein, hFc Tag

Recombinant mouse GITR Ligand protein with N-terminal human Fc tag
5/5

$550.00

Cat.#:  12190

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     12190
Product Name:   Mouse GITR Ligand Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   Tnfsf18
Target:    GITR Ligand
UNIPROT ID:    Q7TS55
Description:    Recombinant mouse GITR Ligand protein with N-terminal human Fc tag
Background:     Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).[UniProtKB/Swiss-Prot Function]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 40.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mGITRL is approximately 40-55 kDa due to glycosylation.
Molecular Characterization:    hFc(Glu99-Ala330) Mouse GITR Ligand(Thr47-Ser173)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Mouse GITR Ligand Protein, hFc Tag on SDS-PAGE under reducing condition.
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