$550.00
| Cat.#: 12177 |
| Product Name: Mouse TIGIT Protein |
| Size : 10 µg, 50 µg and 100 µg |
| Synonyms: T-cell immunoreceptor with Ig and ITIM domains;V-set and transmembrane domain-containing protein 3;Vstm3 |
| Target: TIGIT |
| UNIPROT ID: A0A0B4J1G6 |
| Description: Recombinant mouse TIGIT protein with C-terminal human Fc tag |
| Background: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009] |
| Species/Host: HEK293 |
| Molecular Weight: The protein has a predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of mTIGIT-hFc is approximately 40-55 kDa due to glycosylation. |
| Molecular Characterization: Mouse TIGIT(Ile28-Pro139) hFc(Glu99-Ala330) |
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Mouse TIGIT Protein, hFc Tag on SDS-PAGE under reducing condition. |
