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NKG2A (DMC298) IgG1 Chimeric mAb

Anti-NKG2A (DMC298) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28197

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28197
Product Name:   Anti-NKG2A(DMC298) IgG1 Chimeric Monoclonal Antibody
Synonyms:   CD159A; NKG2; NKG2A
Description:    Anti-NKG2A antibody(DMC298) IgG1 Chimeric Monoclonal Antibody
Background:    Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family; also called NKG2 family; which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member; KLRD1:CD94; and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human NKG2A
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-NKG2A (DMC298) on Expi293 cells transfected with human NKG2A (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).