Subtotal:
$445.00
$4,400.00
| Cat.#: 11070 | ||
| Product Name: Human NPC1L1 Full Length Protein | ||
| Size : 10 µg, 50 µg and 100 µg | ||
| Synonyms: LDLCQ7; NPC11L1; SLC65A2 | ||
| Target: NPC1L1 | ||
| UNIPROT ID: Q9UHC9 | ||
| Description: Human NPC1L1 full length protein-synthetic nanodisc | ||
| Background: The protein is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. | ||
| Species/Host: HEK293 | ||
| Molecular Weight: The human full length NPC1L1 protein has a MW of 148.7 kDa | ||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||
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