NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$219.00
Orai1-L2 Polyclonal Antibody
Cat. #: 21002 |
Gene Symbol: Orai1 |
Description: Anti-Orai1-L2 Rabbit Polyclonal Antibody |
Background: Store-operated calcium channels (SOCs) play essential functions in various physiological processes. Orai1 (also named CRACM1) is a critical molecular component of SOCs. Orai1 protein is a ~35 kDa plasma membrane protein with 4 transmembrane domains. Human patients with a severe combined immunodeficiency (SCID) syndrome possess point mutations in Orai1 gene. |
Immunogen: A peptide from the extracellular loop 2 region of human Orai1 |
Applications: ELISA, WB |
Recommended Dilutions: ELISA: 1:1000-1:5000, WB: 1:1000-1:2000, IHC: 1:100-1:200 |
Concentration: |
Host Species: Rabbit |
Format: Liquid |
Clonality: Polyclonal |
Isotype: IgG |
Purity: Immunogen affinity purified |
Preservative: 0.01% sodium azide |
Constituents: 50mM NaHCO3-Glycine, 0.15M NaCl,, pH7.4 |
Species Reactivity: Orai1-L2 antibody recognizes Orai1 from human. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot: Human Orai1 plasmid DNA was transiently transfected into HEK-293 cells. Whole-cell lysate was used for western blot in the absence (A) or presence (B) of antigen peptide. |