| Cat.#: 28461 |
| Product Name: Anti-OX40(DM116) Rabbit Monoclonal Antibody |
| Synonyms: TNFRSF4; OX40; CD134; OX40L receptor; ACT35; TXGP1L |
| Description: Anti-OX40 antibody(DM116) Rabbit Monoclonal Antibody |
| Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1:BCL2-XL; and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4 T cell response; as well as in T cell-dependent B cell proliferation and differentiation. |
| Applications: ELISA; Flow Cyt |
| Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100 |
| Host Species: Rabbit |
| Isotype: Rabbit IgG |
| Purification: Purified from cell culture supernatant by affinity chromatography |
| Species Reactivity: Human OX40 |
| Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human OX40 protein, hFc-His tagged protein 11150 can bind Rabbit anti-OX40 monoclonal antibody (clone: DM116) in a linear range of 6-70 ng/ml. | 
Figure 2. Flow cytometry analysis with Anti-OX40 (DM116) on Expi293 cells transfected with human OX40 (Blue histogram) or Expi293 transfected with irrelevant protein(Red histogram). |
|
