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PMEL (DMC420) IgG1 Chimeric mAb

Anti-PMEL (DMC420) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28214

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28214
Product Name:   Anti-PMEL(DMC420) IgG1 Chimeric Monoclonal Antibody
Synonyms:   D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL17; SI; SIL; SILV
Description:    Anti-PMEL antibody(DMC420) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes; which are the melanin-producing organelles in melanocytes; and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human PMEL
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-PMEL (DMC420) on Expi293 cells transfected with human PMEL (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).