| Cat.#: 28521 |
| Product Name: Anti-TIGIT(DM178) Rabbit Monoclonal Antibody |
| Synonyms: TIGIT;VSIG9;VSTM3 |
| Description: Anti-TIGIT antibody(DM178) Rabbit Monoclonal Antibody |
| Background: This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. |
| Applications: ELISA; Flow Cyt |
| Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100 |
| Host Species: Rabbit |
| Isotype: Rabbit IgG |
| Purification: Purified from cell culture supernatant by affinity chromatography |
| Species Reactivity: Human TIGIT |
| Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). |
Figure 1. Flow cytometry analysis with Anti-TIGIT (DM178) on Expi293 cells transfected with human TIGIT (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram). | 
Figure 2. Competition assay demonstrating DM178 blockade of CD155 binding to Jurkat cell line transfected with human TIGIT,and competitive activity is better than etigilimab biosimilar. |
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