Email:   |  Call: 6109452007

TNFSF11 (DMC267) IgG1 Chimeric mAb

Anti-TNFSF11 (DMC267) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28175

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28175
Product Name:   Anti-TNFSF11(DMC267) IgG1 Chimeric Monoclonal Antibody
Synonyms:   CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
Description:    Anti-TNFSF11 antibody(DMC267) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT:PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6; which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes; and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human TNFSF11
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-TNFSF11 (DMC267) on Expi293 cells transfected with human TNFSF11 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).