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TNFSF15 (DMC464) IgG1 Chimeric mAb

Anti-TNFSF15 (DMC464) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28240

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28240
Product Name:   Anti-TNFSF15(DMC464) IgG1 Chimeric Monoclonal Antibody
Synonyms:   TL1; VEGI
Description:    Anti-TNFSF15 antibody(DMC464) IgG1 Chimeric Monoclonal Antibody
Background:    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells; but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21:DR6. It can activate NF-kappaB and MAP kinases; and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation; and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq; Feb 2011]
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human TNFSF15
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-TNFSF15 (DMC464) on Expi293 cells transfected with human TNFSF15 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).