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TSLP (DMC426) IgG1 Chimeric mAb

Anti-TSLP (DMC426) IgG1 Chimeric Monoclonal Antibody
5/5

$445.00

Cat.#:  28220

   Size:   100 μg

In Stock

            Product Description          
Cat.#:   28220
Product Name:   Anti-TSLP(DMC426) IgG1 Chimeric Monoclonal Antibody
Synonyms:   TSLP
Description:    Anti-TSLP antibody(DMC426) IgG1 Chimeric Monoclonal Antibody
Background:    This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c( ) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases; including asthma; allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition; the shorter (predominant) isoform is an antimicrobial protein; displaying antibacterial and antifungal activity against B. cereus; E. coli; E. faecalis; S. mitis; S. epidermidis; and C. albicans. Alternative splicing of this gene results in multiple transcript variants.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human TSLP
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. TSLP protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-TSLP (DMC426) on Expi293 cells transfected with human TSLP (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).
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