NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$429.00
Cat. #: 26105 | |
Size: 100 µL | |
Description: Anti-MMAE Monoclonal antibody(8B4) | |
Background: Monomethyl auristatin E (MMAE), a potent mitotic inhibitor derived from dolastatin 10, plays a pivotal role in antibody-drug conjugates (ADCs) for cancer therapy. ADCs precisely target cancer cells, minimizing collateral damage. However, ADC development requires thorough pharmacokinetic and safety assessments. Our specialized anti-MMAE antibodies streamline this process, facilitating PK analysis and safety evaluation. These antibodies are crucial tools for optimizing ADCs, ensuring their effectiveness and safety in revolutionizing cancer treatment. | |
Immunogen: Monomethyl auristatin E | |
Applications: ELISA | |
Recommended Dilutions: ELISA 1:5000-10000 | |
Concentration: 1 mg/ml | |
Host Species: Rabbit | |
Clonality: Monoclonal | |
Clone ID: 8B4 | |
Isotype: Rabbit IgG | |
Purity: Purified from cell culture supernatant by affinity chromatography | |
Formulation & Reconstitution:Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. | |
Storage Conditions: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | |
Figure 1. Elisa plates were pre-coated with IgG-MMAE (0.2 μg/per well). Serial diluted anti-MMAE monoclonal antibody (26105) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-MMAE monoclonal antibody binding with IgG-MMAE is 2.274 ng/ml. |