$429.00
| Cat. #: 26105 | |
| Size: 100 µL | |
| Description: Anti-MMAE Monoclonal antibody(8B4) | |
| Background: Monomethyl auristatin E (MMAE), a potent mitotic inhibitor derived from dolastatin 10, plays a pivotal role in antibody-drug conjugates (ADCs) for cancer therapy. ADCs precisely target cancer cells, minimizing collateral damage. However, ADC development requires thorough pharmacokinetic and safety assessments. Our specialized anti-MMAE antibodies streamline this process, facilitating PK analysis and safety evaluation. These antibodies are crucial tools for optimizing ADCs, ensuring their effectiveness and safety in revolutionizing cancer treatment. | |
| Immunogen: Monomethyl auristatin E | |
| Applications: ELISA | |
| Recommended Dilutions: ELISA 1:5000-10000 | |
| Concentration: 1 mg/ml | |
| Host Species: Rabbit | |
| Clonality: Monoclonal | |
| Clone ID: 8B4 | |
| Isotype: Rabbit IgG | |
| Purity: Purified from cell culture supernatant by affinity chromatography | |
| Formulation & Reconstitution:Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. | |
| Storage Conditions: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | |
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Figure 1. Elisa plates were pre-coated with IgG-MMAE (0.2 μg/per well). Serial diluted anti-MMAE monoclonal antibody (26105) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-MMAE monoclonal antibody binding with IgG-MMAE is 2.274 ng/ml. |
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