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Mouse NKG2D Protein, hFc Tag

Recombinant mouse NKG2D protein with N-terminal human Fc tag
5/5

$550.00

Cat.#:  12194

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     12194
Product Name:   Mouse NKG2D Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   NK cell receptor D;CD314;Klrk1;Nkg2d
Target:    NKG2D
UNIPROT ID:    O54709
Description:    Recombinant mouse NKG2D protein with N-terminal human Fc tag
Background:     Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8( ) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1.[UniProtKB/Swiss-Prot Function]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 42.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mNKG2D is approximately 35-55 kDa due to glycosylation.
Molecular Characterization:    hFc(Glu99-Ala330) Mouse NKG2D(Phe90-Val232)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Mouse NKG2D Protein, hFc Tag on SDS-PAGE under reducing condition.
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