Subtotal:
$445.00
$445.00
| Cat.#: 28444 | ||
| Product Name: Anti-CD40(DM101) Rabbit Monoclonal Antibody | ||
| Synonyms: CD40; Bp50; CDW40; MGC9013; TNFRSF5; p50 | ||
| Description: Anti-CD40 antibody(DM101) Rabbit Monoclonal Antibody | ||
| Background: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching; memory B cell development; and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand; which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation; and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. | ||
| Applications: ELISA; Flow Cyt | ||
| Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100 | ||
| Host Species: Rabbit | ||
| Isotype: Rabbit IgG | ||
| Purification: Purified from cell culture supernatant by affinity chromatography | ||
| Species Reactivity: Human CD40 | ||
| Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). | ||
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