$495.00
EGFR(E746-A750)del
| Cat. #: 26235 |
| Gene Symbol: EGFR/HER1/ERBB1 |
| Description: Anti-EGFR(E746-A750)del Mouse Monoclonal Antibody |
| Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR). |
| Immunogen: A synthetic peptide from the internal region of EGFR which includes the deletion of E746-A750, human origin. |
| Applications: ELISA, WB |
| Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:500-1:1000 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes EGFR(E746-A750), but not wild type EGFR of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid freeze/thaw cycles |
Western blot:
Western blot analysis of recombinant EGFR(E746-A750) and wild type proteins.
Purified His-tagged EGFR(E746-A750)del protein (aa 702-987) and wild type protein (aa 702-987) were blotted with anti- EGFR(E746-A750)del mouse antibody (Cat. #26235).
