Subtotal:
$248.00
$555.00
| Cat.#: 11284 | ||||
| Product Name: Human B7-2 Protein | ||||
| Size : 10 µg, 50 µg and 100 µg | ||||
| Synonyms: CD86;B7-2;B70;CD28LG2;LAB72;MGC34413 | ||||
| Target: B7-2 | ||||
| UNIPROT ID: P42081 | ||||
| Description: Recombinant human B7-2 protein with C-terminal human Fc tag | ||||
| Background: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms. | ||||
| Species/Host: HEK293 | ||||
| Molecular Weight: The protein has a predicted molecular mass of 51.5 kDa after removal of the signal peptide. | ||||
| Molecular Characterization: B7-2(Leu26-Pro247) hFc(Glu99-Ala330) | ||||
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. | ||||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||||
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