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Human BCMA Protein, mFc Tag

Recombinant human BCMA protein with C-terminal mouse Fc tag


Cat.#:  11163

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11163
Product Name:   Human BCMA Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   TNFRSF17;CD269;BCM;BCMA
Target:    BCMA
UNIPROT ID:    Q02223
Description:    Recombinant human BCMA protein with C-terminal mouse Fc tag
Background:     B-cell maturation protein (BCMA or BCM), is also known as Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), which is encoded by the TNFRSF17 gene. TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). This receptor is expressed in immune organs and mature B cell lines. BCMA promotes B-cell survival and plays a role in the regulation of humoral immunity. BCMA can activate NF-kappa-B and JNK.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 32.1 kDa after removal of the signal peptide.
Molecular Characterization:    BCMA(Met1-Ala54) mFc(Pro99-Lys330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human BCMA, mFc Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human BAFF, hFc tagged protein 11169 can bind Human BCMA, mFc tagged protein (11163) in a linear range of 0.03-15.625 ng/ml.

Figure 3. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human BCMA, mFc tagged protein (11163) can bind Anti-BCMA Neutralizing antibody 28037 in a linear range of 0.64-80.0 ng/ml.

Figure 4. Flow cytometry analysis with 1µg/ml Human BCMA Protein, mFc tag (11163) on Expi293 cells transfected with human BAFF (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).