$415.00
Cat.#: 11456 |
Product Name: Human CCR6 Protein |
Size : 10 µg, 50 µg and 100 µg |
Synonyms: BN-1;C-C CKR-6;CC-CKR-6;CCR-6;CD196;CKR-L3;CKRL3;CMKBR6;DCR2;DRY6;GPR29;GPRCY4;STRL22 |
Target: CCR6 |
UNIPROT ID: P51684 |
Description: Recombinant Human CCR6 with C-terminal human Fc tag |
Background: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] |
Species/Host: HEK293 |
Molecular Weight: The protein has a predicted molecular mass of 31.6 kDa after removal of the signal peptide. The apparent molecular mass of CCR6-hFc is approximately 35-55 kDa due to glycosylation. |
Molecular Characterization: CCR6(Met1-Leu47) hFc(Glu99-Ala330) |
Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human CCR6 Protein, hFc Tag on SDS-PAGE under reducing condition. |