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Human EGFRVIII Protein, His Tag

Recombinant Human EGFRVIII Protein with C-terminal 6XHis tag


Cat.#:  11977

   Size:   100 μg

In Stock

            Product Description          
Cat.#:     11977
Product Name:   Human EGFRVIII Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   EGFR;RBB;RBB1;ER1;IG61;ENA
Target:    EGFRVIII
UNIPROT ID:    P00533
Description:    Recombinant Human EGFRVIII Protein with C-terminal 6xHis tag
Background:     The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 39.5 kDa after removal of the signal peptide. The apparent molecular mass of EGFRVIII-His is approximately 55-100 kDa due to glycosylation.
Molecular Characterization:    EGFRVIII(Leu25-Ser645 △267aa) 6×His tag
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human EGFRVIII Protein, His Tag on SDS-PAGE under reducing condition.