Subtotal:
$347.00
$445.00
| Cat.#: 11351 | ||
| Product Name: Human IL4RA Protein | ||
| Size : 10 µg, 50 µg and 100 µg | ||
| Synonyms: CD124;IL-4RA;IL4RA | ||
| Target: IL4RA | ||
| UNIPROT ID: P24394 | ||
| Description: Recombinant Human IL4RA with C-terminal mouse Fc tag | ||
| Background: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. | ||
| Species/Host: HEK293 | ||
| Molecular Weight: The protein has a predicted molecular mass of 49.8 kDa after removal of the signal peptide.The apparent molecular mass of IL4RA-mFc is approximately 70-100 kDa due to glycosylation. | ||
| Molecular Characterization: IL4RA(Met26-His232) mFc(Pro99-Lys330) | ||
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. | ||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||
|
