$479.00
| Cat.#: 11265 |
| Product Name: Human P2RX7 Protein |
| Size : 10 µg, 50 µg and 100 µg |
| Synonyms: P2X7 |
| Target: P2RX7 |
| UNIPROT ID: Q99572 |
| Description: Recombinant human P2RX7 protein with N-terminal human Fc tag |
| Background: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] |
| Species/Host: HEK293 |
| Molecular Weight: The protein has a predicted molecular mass of 59.2 kDa after removal of the signal peptide. The apparent molecular mass of hFc-P2RX7 is approximately 55-70 kDa due to glycosylation. |
| Molecular Characterization: hFc(Glu99-Ala330) P2RX7(Ser47-Val334) |
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human P2RX7 Protein, hFc Tag on SDS-PAGE under reducing condition. |
