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Human Trop2 Protein, mFc-His Tag

Recombinant human Trop2 protein with C-terminal mouse Fc and 6XHis tag


Cat.#:  11304

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11304
Product Name:   Human Trop2 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   TACSTD2;A733-1;1S1;ROP2
Target:    Trop2
UNIPROT ID:    P09758
Description:    Recombinant human Trop2 protein with C-terminal mouse Fc and 6xHis tag
Background:     This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 54.9 kDa after removal of the signal peptide.The apparent molecular mass of Trop2-mFc-His is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    Trop2(His27-Thr274) mFc(Pro99-Lys330) 6×His tag
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human Trop2 Protein, mFc-His Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human Trop2, mFc-His tagged protein (11304) can bind Anti-Trop2 Neutralizing antibody 28032 in a linear range of 0.13-16.0 ng/ml.