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JAM-A (DMC278) IgG1 Chimeric mAb

Anti-JAM-A (DMC278) IgG1 Chimeric Monoclonal Antibody
5/5

$445.00

Cat.#:  28186

   Size:   100 μg

In Stock

            Product Description          
Cat.#:   28186
Product Name:   Anti-JAM-A(DMC278) IgG1 Chimeric Monoclonal Antibody
Synonyms:   CD321; JAM;JAM1; JAMA; JCAM; KAT; PAM-1
Description:    Anti-JAM-A antibody(DMC278) IgG1 Chimeric Monoclonal Antibody
Background:    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets; forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition; the encoded protein can act as (1) a receptor for reovirus; (2) a ligand for the integrin LFA1; involved in leukocyte transmigration; and (3) a platelet receptor. Multiple 5' alternatively spliced variants; encoding the same protein; have been identified but their biological validity has not been established.
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human JAM-A
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. JAM-A protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-JAM-A (DMC278) on Expi293 cells transfected with human JAM-A (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and  Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).
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