Email: info@neweastbio.com   |  Call: 6109452007

Mouse B7-2 Protein, hFc Tag

Recombinant mouse B7-2 protein with C-terminal human Fc tag
5/5

$569.00

Cat.#:  12170

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     12170
Product Name:   Mouse B7-2 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   CD86;ETC-1
Target:    B7-2
UNIPROT ID:    P42082
Description:    Recombinant mouse B7-2 protein with C-terminal human Fc tag
Background:     This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 51.4 kDa after removal of the signal peptide. The apparent molecular mass of mB7-2-hFc is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    Mouse B7-2(Val24-Glu245) hFc(Glu99-Ala330)
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Mouse B7-2 Protein, hFc Tag on SDS-PAGE under reducing condition.
          Publications